A cancer patient and his wife say they feel "destroyed" by the government's decision not to roll out a Covid protection for people with weakened immune systems.
The Department of Health said it would not be buying doses of the Evusheld injection without more evidence about its effectiveness against Omicron.
Scott Brigden, from Hedon, East Yorkshire, will continue shielding, his wife Nikola said.
Charities said they were disappointed.
Mrs Brigden, whose husband was diagnosed with mantle cell lymphoma in June 2021, said: "We are both absolutely destroyed by this decision. So many people have been let down.
"It's almost as though these people, some of society's most vulnerable, have been thrown to the wasteland."
Evusheld, developed by AstraZeneca, contains two antibodies against Covid that boost protection for those whose immune systems do not respond well to vaccines.
Clinical trials in adults showed a 77% reduction in the risk of developing Covid symptoms for at least six months after a single dose of the drug.
AstraZeneca is selling Evusheld in 32 countries including the US, Canada and parts of the EU.
However, the UK government said it wanted evidence of longer protection against the Omicron variant circulating now.
Mrs Brigden said: "It makes no sense. Thirty-two other countries are using it. Why not this country?
"It would help ease the burden on the NHS because all these people would be protected from Covid complications."
Blood Cancer UK said many people would be "left feeling let down" by the decision.
"We have been unable to mix with family and friends since March 2021," said Mrs Brigden.
"Scott wants to return to work but we can't risk it. We are going to have to keep isolating until at least next April."
A review by the health watchdog NICE will get under way this autumn, but is not expected to report until April next year.
Follow BBC East Yorkshire and Lincolnshire on Facebook, Twitter, and Instagram. Send your story ideas to yorkslincs.news@bbc.co.uk.
Covid antibody protection ruled out for vulnerable
Cancer patient in call for Evusheld
'Forgotten' couple still shielding from Omicron
AstraZeneca UK
Department of Health and Social Care
Blood Cancer UK
Paedophile with 'monstrous side' researched medical procedure to remove twisted urges
Beloved Scunthorpe music venue saved as plans to build new homes fall through
Meet the the Dales farming family who have helped run Kilnsey Show since 1897
'Brutal' Doncaster thug horrifically attacked woman and left her with life-changing injuries during Cleethorpes assault
Opportunity to discuss council’s climate change strategy in Pocklington
MP Sir Greg Knight welcomes action to tackle East Riding's fast food litter
Pakistan appeals for flood aid as 119 more die
Two US warships sail through Taiwan Strait
The moment India skyscrapers turned to dust. Video
'I lost the will to leave home because of racist slur'
Controversy hits Queen's representative in Australia
Can the world cope without Russian oil and gas?
How we get humans back to the Moon
Electricity and drought killing white storks. Video
Why Edwards' triumph is a real-life Rocky story
The unusual treaty still enforced after 600 years
A photographic mission to show us the Moon
Party photos and scandal: What now for Sanna Marin?
Why Dijon mustard disappeared from France
Ten of the world's most ingenious buildings
A pizza topping that divides the world
© 2022 BBC. The BBC is not responsible for the content of external sites. Read about our approach to external linking.
